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Synthesis and antiviral activity of several quinoline derivatives

The antiviral activity of 2-substituted and 2,6-disubstituted quinoline-4-carboxylic acids and their derivatives has been studied against orthopoxviruses on Vero and MK-2 cell cultures. High activity has been found for 2-(1,1′-biphenyl-4-yl)quinoline-4-carboxylic acid.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 45, No. 5, pp. 9 – 11,May, 2011.

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Zemtsova, M.N., Zimichev, A.V., Trakhtenberg, P.L. et al. Synthesis and antiviral activity of several quinoline derivatives. Pharm Chem J 45, 267–269 (2011).

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Key words

  • quinolinecarboxylic acids
  • acid derivatives
  • biological activity