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Comparative study of quantitative determination of amoxicillin in capsules by mercurimetry and liquid chromatography

Assay of amoxicillin in capsules performed in accordance with the US Pharmacopeia by liquid chromatography was compared with a method based on mercurimetric titration, developed by ourselves, in which the internal indicator was an azo derivative of theophylline, i.e., benzenesulfonamide, N-(2,6-dimethoxy-4-pyrimidinyl)-4-[(4-methylamino-5-methylcarbamoyl)]azo2. The analysis results showed that mercurimetric assay was specific and easily performed in laboratory conditions and can be used as an alternative method.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 45, No. 4, pp. 53 – 56, April, 2011.

2CA Index Name, i.e., chemical name according to the rules and conventions of the “9th Collective Index of the Chemical Abstracts Service.”

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Aliev, A.M., Babazade, G.M. Comparative study of quantitative determination of amoxicillin in capsules by mercurimetry and liquid chromatography. Pharm Chem J (2011). https://doi.org/10.1007/s11094-011-0609-8

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  • DOI: https://doi.org/10.1007/s11094-011-0609-8

Key words

  • Amoxicillin
  • liquid chromatography
  • mercurimetry
  • internal indicator
  • theophylline azo derivative