Skip to main content

Design, synthesis and antibacterial activity of substituted phenylthiazolyl s-triazines

Substituted s-triazine derivatives are believed to exert their antibacterial effects by nonspecific mechanisms. We have assessed the extent to which physicochemical properties can be used to promote discriminative activity of these compounds. In the search for new and efficient antibacterial agents, a series of substituted phenylthiazolyl s-triazines were synthesized and screened for their in vitro antibacterial activity against three Gram positive (Bacillus subtilis, Bacillus cereus, Staphylococcus aureus) and three Gram-negative (Salmonella typhi, Escherichia coli, Klebsiella aerogenes) bacterial species by the broth dilution technique as recommended by European Committee for antimicrobial susceptibility testing (EUCAST) with reference to streptomycin.

This is a preview of subscription content, access via your institution.

Scheme 1
Fig. 1
Fig. 2

References

  1. A. Ghaib, S. Menager, P. Verite and O. H. Lafont, Farmaco 57, 109 (2002).

    PubMed  Article  CAS  Google Scholar 

  2. M. E. Sanders and M. M. Ames, Tetrahedron Lett. 26, 5247 (1985).

    Article  CAS  Google Scholar 

  3. K. Srinivas, U. Srinivas, K. Bhanuprakash, K. Harakishore, et al., Bioorg. Med. Chem. Lett., 41, 1240 (2006).

    CAS  Google Scholar 

  4. Z. Brzozowski, F. Saczewski and M. Gdamiec, Eur. J. Med. Chem., 35, 1053 (2000).

    PubMed  Article  CAS  Google Scholar 

  5. V. K. Pandey, S. Tusi, Z. Tusi, M. Joshi and S. Bajpai, Acta Pharm., 54, 1 (2004).

    PubMed  CAS  Google Scholar 

  6. J. P. Tarayre, H. Cousse, G. Mouzin, H. Lauressergues, et al., US Patent no. 4225610 (1980).

  7. J. B. Dickey, E. B. Torne, M. S. Bloom, W. H. Moore, et al., J Org. Chem., 24(2), 187 (1959).

    Article  CAS  Google Scholar 

  8. J. T. Thruston, J. R. Dudley, D. W. Kaiser, I. Henbleikner, et al., J. Am. Chem. Soc., 73(7), 2981 (1951).

    Article  Google Scholar 

Download references

Acknowledgements

The authors acknowledge the valuable contributions made to their work by the AICTE (New Delhi) for grating a scholarship and Lonza (Switzerland) for arranging gift sample of cyanuric chloride.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to P. Gahtori.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Gahtori, P., Das, A. & Mishra, R. Design, synthesis and antibacterial activity of substituted phenylthiazolyl s-triazines. Pharm Chem J 1 (2011). https://doi.org/10.1007/s11094-011-0607-x

Download citation

  • Received:

  • Published:

  • DOI: https://doi.org/10.1007/s11094-011-0607-x

Key words

  • Bacterial resistance
  • s-Triazine
  • Physicochemical properties
  • Broth dilution technique
  • Antibacterial activity