Design, synthesis and antibacterial activity of substituted phenylthiazolyl s-triazines

Substituted s-triazine derivatives are believed to exert their antibacterial effects by nonspecific mechanisms. We have assessed the extent to which physicochemical properties can be used to promote discriminative activity of these compounds. In the search for new and efficient antibacterial agents, a series of substituted phenylthiazolyl s-triazines were synthesized and screened for their in vitro antibacterial activity against three Gram positive (Bacillus subtilis, Bacillus cereus, Staphylococcus aureus) and three Gram-negative (Salmonella typhi, Escherichia coli, Klebsiella aerogenes) bacterial species by the broth dilution technique as recommended by European Committee for antimicrobial susceptibility testing (EUCAST) with reference to streptomycin.