Skip to main content
SpringerLink
Log in

Quantitative nmr spectroscopy for quality control of drugs and pharmaceuticals

  • Structure of Chemical Compounds, Methods of Analysis and Process Control
  • Published:
Pharmaceutical Chemistry Journal Aims and scope

Results of a comparative analysis of the use of quantitative NMR spectroscopy for the quality control of pharmaceuticals and drugs are presented. Diquertin, the active principle of which is the common flavonoid dihydroquercetin (taxifolin, 3,3′,4′,5,7-pentahydroxyflavanone), was used as an example. Quantitative 1H NMR spectroscopy can be recommended on the basis of this comparative analysis for use when it is necessary to identify all possible impurities or to confirm the absence of toxic contaminants and also for rapid analysis of samples.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. D. W. T. Claridge, High Resolution NMR Techniques in Organic Chemistry, Elsevier Ltd., (2009).

  2. O. M. Andersen and K. R. Markham, Flavonoids. Chemistry, Biochemistry and Applications, CRC, Taylor & Francis, Boca Raton (2006).

  3. Handbook of Quality Control Methods and Safety of Biologically Active Food Additives [in Russian], P 4.1.1672-03, Food Institute, RAMS, Moscow (2003).

  4. H. Matsumoto, S. Tebayashi, Y. Kuwahara, et al., J. Pestic. Sci., 19, 181 – 186 (1994).

    CAS  Google Scholar 

  5. A. P. Es_kin, V. A. Levdanskii, and N. I. Polezhaeva, Khim. Rastit. Syr’ya, No. 3, 43 – 46 (1998).

  6. A. Braune, M. Gutschow,W. Engst, and M. Blaut, Appl. Environ. Microbiol., 5558 – 5567 (2001).

  7. A. M. Savvateev, Author’s Abstract of a Candidate Dissertation in Pharmaceutical Sciences, Moscow (2007).

  8. S. Z. Ivanova, T. E. Fedorova, L. A. Ostrukhova, et al., Khim. Rastit. Syr’ya, No. 4, 21 – 24 (2001).

    Google Scholar 

  9. Y. Wei, X. Chen, X. Jiang, et al., J. Food Compos. Anal., 22(2), 154 – 157 (2009).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. People’s Friendship University of Russia, Moscow, Russia

    V. V. Podgorskii, A. S. Mikhalev & G. A. Kalabin

Authors
  1. V. V. Podgorskii
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. S. Mikhalev
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. A. Kalabin
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 45, No. 3, pp. 52 – 55, March, 2011.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Podgorskii, V.V., Mikhalev, A.S. & Kalabin, G.A. Quantitative nmr spectroscopy for quality control of drugs and pharmaceuticals. Pharm Chem J 45, 194–197 (2011). https://doi.org/10.1007/s11094-011-0591-1

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-011-0591-1

Key words

Search

Navigation