The reaction of methyl esters of acylpyruvic acids, 4-aminophenols, and aromatic aldehydes leads to the formation of 1-(4-hydroxyphenyl)-4-acyl-5-aryl-3-hydroxy-3-pyrrolin-2-ones. The proposed structures of the synthesized compounds were confirmed by IR and PMR spectroscopy. The antibacterial activity of some of the newly synthesized compounds was studied.
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V. L. Gein, Tetrahydropyrrole- and tetrahydrofuran-2,3-diones [in Russian], PSPA, Perm (2004).
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 45, No. 3, pp. 33 – 35, March, 2011.
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Gein, V.L., Armisheva, M.N., Rassudikhina, N.A. et al. Synthesis and antimicrobial activity of 1-(4-hydroxyphenyl)-4-acyl-5-aryl-3-hydroxy-3-pyrrolin-2-ones. Pharm Chem J 45, 162–164 (2011). https://doi.org/10.1007/s11094-011-0584-0
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DOI: https://doi.org/10.1007/s11094-011-0584-0