Some novel derivatives of quinazolinone including 2-[2-(2, 6-dichlorophenyl)amino]phenylmethyl-3-{4-[2-(substituted phenyl)-4-oxo-thiazolidin-3-yl]phenylsulfonamido-1-yl}-6-bromoquinazolin-4(3H)ones (4a – 4l) were prepared from 2-[2-(2, 6-dichlorophenyl) amino]phenylmethyl-3-{[4-(N-substituted arylidene)phenyl]-sulfonamide-1-yl}-6-bromo quinazolin-4(3H)ones (3a – 3l). Twenty four synthesized compounds were screened in vitro for their antibacterial and antifungal activities. Minimum inhibitory concentration (MIC) values of all the twenty four compounds were determined. Some of these compounds exhibited significant antimicrobial activity.
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Acknowledgement
The authors thank the Professor and Head, Department of Chemistry, Veer Narmad South Gujarat University, Surat for laboratory facilities. Also wish to thank C. D. R. I., Lucknow for elemental analysis, S. A. I. F., Chandigarh for 1H NMR and 13C NMR spectral analysis and D. Rajani, Microcare Laboratory, Surat, for antimicrobial activity testing.
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Patel, N.B., Patel, V.N. Synthesis, antibacterial and antifungal activities of novel thiazolidinyl sulfonamides of quinazolin-4(3H)ones. Pharm Chem J 44, 438–445 (2010). https://doi.org/10.1007/s11094-010-0486-6
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DOI: https://doi.org/10.1007/s11094-010-0486-6