A series of previously unreported 2-alkyl-1-(2-chloromethylcarbonylethoxy)pyrroles have been synthesized via reaction of 2-alkly-1-(2-hydroxyethyl)pyrroles with chloroacetyl chloride and reaction of the intermediates with secondary amines to give 2-alkyl-1-[2-diethylamino(morpholino)methylcarbonylethoxy]pyrroles. Their antimicrobial activity has been studied. It is established that electron-accepting substituents in the methylcarbonylethoxy chain increase whereas electron-donating ones decrease the antimicrobial activity of the pyrroles in the order chlorine > morpholine > diethylamine.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 44, No. 8, pp. 28–30, August, 2010.
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Hajili, R.A., Gakhramanov, R.F., Mamedova, A.A. et al. Synthesis and antimicrobial activity of 2-alkyl-1-[2′-chloro(diethylamino, morpholino)methylcarbonylethoxy]pyrroles. Pharm Chem J 44, 430–432 (2010). https://doi.org/10.1007/s11094-010-0484-8
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DOI: https://doi.org/10.1007/s11094-010-0484-8