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Antioxidant and antiradical properties of new amino-acid derivatives of aminoalcohols

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Pharmaceutical Chemistry Journal Aims and scope

The antioxidant, antiradical, and membranotropic properties of newly synthesized compounds of the group of N-[3-hydroxy-3-(p-substituted phenyl)-1-propyl] amino acids were studied on model systems in vitro.According to the results, amino-acid derivatives of aminopropanols did not exhibit any significant antioxidant or antiradical activity as evidenced by Fe(II)-stimulated ascorbate-dependent peroxidation, by spectrophotometric monitoring of a decrease in the concentration of stable 2,2-diphenyl-1-picrylhydrazyl radical, or by photochemiluminescence techniques. However, these compounds revealed a membrane-stabilizing effect preventing hemolytic destruction of cells under conditions of H2O2-stimulated oxidative stress of erythrocytes. In this respect, derivatives of glycine, leucine, and methionine were most interesting.

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Authors and Affiliations

  1. Scientific Center of Radiation Medicine and Burns, Ministry of Public Health of Armenia, Yerevan, 0048, Armenia

    M. G. Malakyan, L. A. Vardevanyan, D. E. Yeghiazaryan & S. A. Badzhinyan

  2. Scientific and Technological Centre of Organic and Pharmaceutical Chemistry, Mndzhoyan Institute of Fine Organic Chemistry, National Academy of Sciences of Armenia, Yerevan, 0048, Armenia

    A. G. Agababyan & G. A. Gevorgyan

Authors
  1. M. G. Malakyan
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  2. L. A. Vardevanyan
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  3. D. E. Yeghiazaryan
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  4. S. A. Badzhinyan
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  5. A. G. Agababyan
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  6. G. A. Gevorgyan
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Corresponding author

Correspondence to L. A. Vardevanyan.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 44, No. 8, pp. 19 – 21, August, 2010.

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Malakyan, M.G., Vardevanyan, L.A., Yeghiazaryan, D.E. et al. Antioxidant and antiradical properties of new amino-acid derivatives of aminoalcohols. Pharm Chem J 44, 421–423 (2010). https://doi.org/10.1007/s11094-010-0481-y

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  • DOI: https://doi.org/10.1007/s11094-010-0481-y

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