Novel bioactive 2-phenyl-3-(4,6-diarylpyrimidin-2-yl)thiazolidin-4-ones 12–22 were synthesized with good yields in a short reaction time by the “one-pot” multicomponent reaction of the appropriate 2-amino-4,6diarylpyrimidines, benzaldehyde and thioglycolic acid under microwave irradiation in the presence of an activated fly ash catalyst in dry medium. The characterization of these compounds was confirmed by melting point, elemental analysis, mass spectrometry, FT-IR spectroscopy, and one-dimensional NMR (1H and 13C) spectroscopic data. In search for new leads toward potent antimicrobial agents, all the synthesized compounds have been tested in vitro for their antibacterial activity against Bacillus subtilis and Micrococcus luteus and antifungal activity against Aspergillus niger, Candida albicans, Candida 6 and Candida 51, and the results are discussed.
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Acknowledgements
The authors are thankful to NMR Research Centre, Indian Institute of Science (Bangalore) for recording spectra. One of the authors (V. K.) is grateful to the Council of Scientific and Industrial Research (CSIR, New Delhi, Republic of India) for providing financial support in the form of CSIR-Senior Research Fellowship (SRF) in Organic Chemistry.
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Kanagarajan, V., Gopalakrishnan, M. One-pot synthesis and in vitro microbiological evaluation of pyrimidinyl thiazolidinones catalyzed by activated fly ash in dry media. Pharm Chem J 44, 374–380 (2010). https://doi.org/10.1007/s11094-010-0471-0
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DOI: https://doi.org/10.1007/s11094-010-0471-0