5-Aryl-4-acyl-3-hydroxy-1-(2,2-dimethoxyethyl)-3-pyrrolin-2-ones were synthesized by the reaction of acylpyruvic acid methyl esters with a mixture of an aromatic aldehyde and aminoacetaldehyde dimethylacetal. The proposed structures are confirmed by IR and PMR spectroscopy. The results of an investigation of the antibacterial and analgesic activity of the synthesized compounds are presented.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
V. L. Gein, Tetrahydropyrrol-and Tetrahydrofuran-2,3-diones [in Russian], Perm (2004).
T. A. Silina, V. L. Gein, L. F. Gein, et al., Khim.-farm. Zh., 37(11), 20–22 (2003).
V. L. Gein, V. S. Platonov, and E. V. Voronina, Khim.-farm. Zh., 38(6), 31–32 (2004).
Author information
Authors and Affiliations
Additional information
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 44, No. 7, pp. 27 – 29, July, 2010.
Rights and permissions
About this article
Cite this article
Gein, V.L., Vychegzhanina, V.N., Levandovskaya, E.B. et al. Synthesis and antibacterial and analgesic activity of 5-aryl-4-acyl-3-hydroxy-1(2,2-dimethoxyethyl)-3-pyrrolin-2-ones. Pharm Chem J 44, 370–373 (2010). https://doi.org/10.1007/s11094-010-0470-1
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11094-010-0470-1