Recent years have seen increasing use of formulations containing sets of compensatory metabolites in the form of short-chain fatty acids (SCFA), i.e., acetic, propionic, butyric, isobutyric, valeric, and isovaleric acids. This has led to the need to adapt existing analytical methods to monitor the presence of SCFA in probiotic formulations. The main task of the present study was to develop an assay for SCFA in formulations based on bacterial substrates. This was addressed using gas chromatography with flame ionization detection.
Similar content being viewed by others
References
B. A. Shenderov, Medical Microbial Ecology and Functional Nutrition [in Russian], Grant’ Press, Moscow (1998), Vol. 1, pp. 28 – 48.
M. D. Ardatskaya, Dissertation for Doctorate in Medical Sciences [in Russian], Moscow (2003).
D. P. Collin, P. G. McCormick, and M. G. Schmidt, J. Clin. Chem., 20, 1235 – 1237 (1974).
Guohua Zhao, M. Nyman, and J. Åke Jönsson, Biomed. Chromatogr., 20(8), 674 – 682 (2005).
L. Brühl and B. Matthöus, Lipid Technol., 20(3), 60 – 63 (2008).
Author information
Authors and Affiliations
Additional information
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 44, No. 6, pp. 50 – 52, June, 2010.
Rights and permissions
About this article
Cite this article
Sheveleva, M.A., Ramenskaya, G.V. Gas chromatographic analysis of short-chain fatty acids in the standardization of medicinal formulations based on bacterial substrates. Pharm Chem J 44, 334–336 (2010). https://doi.org/10.1007/s11094-010-0462-1
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11094-010-0462-1