Polymer complexes of aminoglycoside antibiotics as bases with low molecular weight water-soluble copolymers of acrylamide (ACR) with acrylic (AA) and methacrylic (MA) acids containing 15 – 20 mol% carboxyl groups were synthesized. Complexes of antibiotics with ACR-MA copolymers were found to be more stable in aqueous and aqueous salt solutions and to have less toxicity in vitro than complexes based on ACR-AA copolymers. All polymer complexes retained high levels of antibacterial activity.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 44, No. 6, pp. 28 – 32, June, 2010.
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Solovskii, M.V., Eropkin, M.Y., Eropkina, E.M. et al. Complexes of aminoglycoside antibiotics with copolymers of acrylamide with acrylic and methacrylic acids. Pharm Chem J 44, 314–318 (2010). https://doi.org/10.1007/s11094-010-0458-x
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DOI: https://doi.org/10.1007/s11094-010-0458-x