The effect of solid dispersion (SD) formation on the solubility of phenazepam has been studied. Phenazepam and its SDs with poly(ethyleneglycol)-1500 (PEG), poly(vinylpyrrolidone)-10000 (PVP), and β-cyclodextrin were studied. The SD with PVP increases both the solubility and the dissolution rate of phenazepam. Results obtained by a complex of physical and chemical methods suggest that the improved release of phenazepam from the SD with PVP is due to solubilization, amorphization, and formation of a colloidal dispersion of the parent drug substance.
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References
S. B. Seredin, Phenazepam. 25 Years in Medical Practice (Scientific Edition) [in Russian], Nauka, Moscow (2007).
M. D. Mashkovskii, Drugs [in Russian], RIA Novaya Volna, Moscow (2007), pp. 76–77.
V. A. Popkov, V. Yu. Reshetnyak, I. I. Krasnyuk, Jr., et al., Farmatsiya, 3, 39–42 (2005).
Yu. V. Skovpen’, Author’s Abstract of a Candidate Dissertation in Pharmaceutical Sciences, Moscow (2002).
I. I. Krasnyuk, Author’s Abstract of a Candidate Dissertation in Pharmaceutical Sciences, Moscow (2003).
I. I. Krasnyuk, Jr., V. A. Popkov, V. Yu. Reshetnyak, et al., Ross. Med. Zh., No. 6, 34–37 (2005).
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 44, No. 5, pp. 42–45, May, 2010.
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Krasnyuk, I.I., Manakhova, O.V., Khabriev, R.U. et al. Increasing the solubility of phenazepam by forming solid dispersions. Pharm Chem J 44, 274–277 (2010). https://doi.org/10.1007/s11094-010-0448-z
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DOI: https://doi.org/10.1007/s11094-010-0448-z