In a search for new leads towards potent antifungal agents against candidiasis, a series of novel (2E)-ethyl-2(2-(2,4-dinitrophenyl)hydrazono)-4-(naphthalen-2-yl)-6-arylcyclohex-3-ene carboxylates 17–24 is synthesized and characterized by their physical and analytical data. In vitro microbiological evaluations for all the newly synthesized compounds against clinically isolated Candida sp. are carried out, and their structure-activity effect is discussed.
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Acknowledgements
The authors are thankful to NMR Research Centre, Indian Institute of Science, Bangalore for recording spectra. One of the authors, V. Kanagarajan, is grateful to the Council of Scientific and Industrial Research (CSIR), New Delhi, Republic of India for providing financial support in the form of a CSIR-Senior Research Fellowship (SRF) in Organic Chemistry.
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Kanagarajan, V., Gopalakrishnan, M. Synthesis and anticandidiasis activity of novel (2E)-ethyl-2-(2-(2,4-dinitrophenyl)hydrazono)-4(naphthalen-2-yl)-6-arylcyclohex-3-ene carboxylates. Pharm Chem J 44, 228–235 (2010). https://doi.org/10.1007/s11094-010-0437-2
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DOI: https://doi.org/10.1007/s11094-010-0437-2