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Pharmaceutical Chemistry Journal

, Volume 44, Issue 4, pp 189–191 | Cite as

Synthesis and antioxidant activity of 3,5-dimethyl-4-hydroxybenzylthiododecane

  • M. B. Plotnikov
  • A. E. Prosenko
  • V. I. Smol’yakova
  • I. S. Ivanov
  • G. A. Chernysheva
  • N. V. Kandalintseva
Article

Abstract

The new multifunctional antioxidant 3,5-dimethyl-4-hydroxybenzylthiododecane (DHBD) demonstrated high activity both in vitro and in vivo. Experiments in vitro showed that the antioxidant activity of DHBD significantly exceeded that of the well-known reference drug ionol. A course of DHBD administration (100 mg/kg, p.o.) significantly decreased the content of lipid peroxidation products in rat brain on the model of long-term incomplete cerebral ischemia.

Key words

3,5-dimethyl-4-hydroxybenzylthiododecane synthesis antioxidant activity 

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Copyright information

© Springer Science+Business Media, Inc. 2010

Authors and Affiliations

  • M. B. Plotnikov
    • 1
  • A. E. Prosenko
    • 2
  • V. I. Smol’yakova
    • 1
  • I. S. Ivanov
    • 1
  • G. A. Chernysheva
    • 1
  • N. V. Kandalintseva
    • 2
  1. 1.State Institute of Pharmacology, Tomsk Scientific Center, Siberian BranchRussian Academy of Medical SciencesTomskRussia
  2. 2.Institute of Antioxidant ChemistryNovosibirsk State Pedagogical UniversityNovosibirskRussia

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