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Synthesis and antioxidant activity of 3,5-dimethyl-4-hydroxybenzylthiododecane

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Abstract

The new multifunctional antioxidant 3,5-dimethyl-4-hydroxybenzylthiododecane (DHBD) demonstrated high activity both in vitro and in vivo. Experiments in vitro showed that the antioxidant activity of DHBD significantly exceeded that of the well-known reference drug ionol. A course of DHBD administration (100 mg/kg, p.o.) significantly decreased the content of lipid peroxidation products in rat brain on the model of long-term incomplete cerebral ischemia.

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Authors and Affiliations

  1. State Institute of Pharmacology, Tomsk Scientific Center, Siberian Branch, Russian Academy of Medical Sciences, Tomsk, Russia

    M. B. Plotnikov, V. I. Smol’yakova, I. S. Ivanov & G. A. Chernysheva

  2. Institute of Antioxidant Chemistry, Novosibirsk State Pedagogical University, Novosibirsk, Russia

    A. E. Prosenko & N. V. Kandalintseva

Authors
  1. M. B. Plotnikov
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  2. A. E. Prosenko
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  3. V. I. Smol’yakova
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  4. I. S. Ivanov
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  5. G. A. Chernysheva
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  6. N. V. Kandalintseva
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 44, No. 4, pp. 25–27, April, 2010.

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Plotnikov, M.B., Prosenko, A.E., Smol’yakova, V.I. et al. Synthesis and antioxidant activity of 3,5-dimethyl-4-hydroxybenzylthiododecane. Pharm Chem J 44, 189–191 (2010). https://doi.org/10.1007/s11094-010-0428-3

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  • DOI: https://doi.org/10.1007/s11094-010-0428-3

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