Pharmaceutical Chemistry Journal

, Volume 44, Issue 1, pp 7–9 | Cite as

Immunomodulating and antistress activity of ecdysterone and turkesterone under immobilization-induced stress conditions in mice

  • G. A. ShakhmurovaEmail author
  • V. N. Syrov
  • Z. A. Khushbaktova

The phytoecdysteroids ecdysterone and turkesterone isolated from Rhaponticum integrifolium and Ajuga turkestanica herbs, respectively, increase the adaptation capacity of mice under immobilization-induced stress conditions. These compounds prevent involution of the thymicolymphatic system, decrease trophic disorders in gastric mucosa, prevent an increase in the weight of adrenal glands and a decrease in them of the content of ascorbic acid and cholesterol (to a much greater degree than does T-activin), and stimulate immunogenesis in animals with experimental immune deficiency developed on the background of immobilization-induced stress.

Key words

ecdysterone turkesterone T-activin immobilization-induced stress immobilization. 


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Copyright information

© Springer Science+Business Media, Inc. 2010

Authors and Affiliations

  • G. A. Shakhmurova
    • 1
    Email author
  • V. N. Syrov
    • 2
  • Z. A. Khushbaktova
    • 2
  1. 1.Nizami Tashkent State Pedagogical UniversityTashkentUzbekistan
  2. 2.Yunusov Institute of the Chemistry of Plant SubstancesAcademy of Sciences of the Republic of UzbekistanTashkentUzbekistan

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