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Antitumor steroids. part 4. synthesis and biological activity of 11β-hydroxyestra-1,3,5(10)-triene derivatives with a bis-(2-chloroethyl)amino-containing substituent in the 11-position

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Pharmaceutical Chemistry Journal Aims and scope

Analogs of 11β-hydroxyestrone and 17α-ethynylestradiol with a cytotoxic bis-(2-chloroethyl)amino-containing substituent were synthesized in two principal steps from the corresponding 11-hydroxysteroids. Introduction of this bulky fragment influences negatively the estrogenic and antitumor activities of the synthesized compounds.

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Authors and Affiliations

  1. Scientific Endocrinological Center, Russian Academy of Medical Sciences, Moscow, 117036, Russia

    V. M. Rzheznikov, L. E. Golubovskaya & B. I. Keda

  2. Blokhin Oncological Research Center, Russian Academy of Medical Sciences, Kashirskoe shosse 24, Moscow, 115478, Russia

    L. P. Sushinina, T. A. Titova, V. N. Tolkachev & Z. S. Smirnova

Authors
  1. V. M. Rzheznikov
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  2. L. E. Golubovskaya
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  3. B. I. Keda
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  4. L. P. Sushinina
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  5. T. A. Titova
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  6. V. N. Tolkachev
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  7. Z. S. Smirnova
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 43, No. 12, pp. 11 – 15, December, 2009.

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Rzheznikov, V.M., Golubovskaya, L.E., Keda, B.I. et al. Search for new drugs. Pharm Chem J 43, 601–605 (2009). https://doi.org/10.1007/s11094-010-0361-5

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  • DOI: https://doi.org/10.1007/s11094-010-0361-5

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