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Development and validation of HPLC method for analysis of some antiretroviral agents in their pharmaceutical dosage forms

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Pharmaceutical Chemistry Journal Aims and scope

Anew analytical method using reversed-phase high performance liquid chromatography (HPLC) has been developed for analysis of four antiretroviral molecules Lamivudine, Abacavir, Zidovudine, and Efavirenz. The proposed method was validated in accordance with the ICH Q2 (R1) validation guidelines by determining its selectivity, linearity, accuracy, and precision. Based on the results, the method is an effective choice to analyze these drugs in their single and combined pharmaceutical dosage forms.

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Authors and Affiliations

  1. Department of Pharmacy, Shri G. S. Institute of Technology & Science, 23 Park Road, Indore, 452003, Madhya Pradesh, India

    Abhinav Garg, Love Kumar Soni & Satish G. Kaskhedikar

  2. Department of Analytical Research & Development, R&D-III, Ranbaxy Research Laboratories, Gurgaon, 122001, Haryana, India

    Kona S. Srinivas, Loveraj Singh, Kamal K. Gupta & Dhananjay Dwivedi

Authors
  1. Abhinav Garg
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  2. Love Kumar Soni
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  3. Satish G. Kaskhedikar
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  4. Kona S. Srinivas
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  5. Loveraj Singh
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  6. Kamal K. Gupta
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  7. Dhananjay Dwivedi
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Correspondence to Satish G. Kaskhedikar.

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Garg, A., Kumar Soni, L., Kaskhedikar, S.G. et al. Development and validation of HPLC method for analysis of some antiretroviral agents in their pharmaceutical dosage forms. Pharm Chem J 43, 369–374 (2009). https://doi.org/10.1007/s11094-009-0305-0

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  • DOI: https://doi.org/10.1007/s11094-009-0305-0

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