A series of condensed heterocycles containing the pyrazolo[1,5-a]pyrimidine moiety were synthesized from 5-amino-3-methyl-4-phenylpyrazole. The spectra of potential biological activity of the synthesized compounds were determined using computer-aided prediction methods, which showed that the most probable properties were corticotropin-releasing hormone antagonism, cyclooxygenase inhibition, and neuroleptic, nootropic, and cardioprotector activity
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 43, No. 6, pp. 3 – 5, June, 2009.
**Deceased.
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Kryl’skii, D.V., Chuvashlev, A.S., Arzamastsev, A.P. et al. Synthesis of new pyrazolo[1,5-a]pyrimidines. Pharm Chem J 43, 294–296 (2009). https://doi.org/10.1007/s11094-009-0301-4
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DOI: https://doi.org/10.1007/s11094-009-0301-4