Reaction of 1-[4-(1-adamantyl)phenoxy]glycidyl ether with amines leads to the corresponding 1-[4-(1-adamantyl) phenoxy]-3-alkyl(dialkyl)amino-2-propanols. The proposed structures of the synthesized compounds are confirmed by IR and NMR spectroscopy. Substances tested by the serial dilution method exhibited a high level of antimicrobial activity.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 43, No. 6, pp. 10 – 13, June, 2009.
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Korotkii, Y.V., Vrynchanu, N.A., Maksimov, Y.N. et al. Synthesis and antimicrobial activity of 1-[4-(1-adamantyl)phenoxy]-3-amino-2-propanol. Pharm Chem J 43, 301–304 (2009). https://doi.org/10.1007/s11094-009-0299-7
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DOI: https://doi.org/10.1007/s11094-009-0299-7