Results of optimization of the composition and technology of solid gelatin capsules with a dry fucus extract (DFE) containing fucoidan (polysaccharide of fucus algae) are presented. The Box-Wilson method of mathematical planning of experiments was used to determine the optimum conditions of DFE granulation in a mixture with lactose. DFE granules were obtained under the established optimum conditions and their processing properties were determined. The final medicinal preparation in the form of DFE 0.2 g pellets in solid gelatin capsules showed high indices of quality and a high degree of bioavailability in in vivo experiments.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 43, No. 6, pp. 22 – 26, June, 2009.
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Obluchinskaya, E.D. Optimizing the composition and technology of capsules containing dry fucus extract. Pharm Chem J 43, 328–332 (2009). https://doi.org/10.1007/s11094-009-0293-0
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DOI: https://doi.org/10.1007/s11094-009-0293-0