The physicochemical conditions for incorporation of the antiviral agent butaminophen into multilamellar liposomes generated by mechanical dispersion were determined. Regimes for vortexing of the liposome-forming mixture to obtain a homogeneous liposome suspension were identified. This liposomal formulation has potential for the development of oral (gelatin capsules) and ointment formulations.
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L. N. Dunets, O. I. Shadyro, G. I. Polozov, et al., Proceedings of the VI Russian National Congress “Humans and Medicines” [in Russian], Moscow (1999), p. 405.
L. N. Dunets, P. T. Petrov, V. E. Spiridonov, et al., Proceedings of the IX Russian National Congress “Humans and Medicines” [in Russian], Moscow (2002). P. 142.
V. G. Pankratov, S. A. Gumbar, O. V. Pankratov, et al., Proceedings of the IX Russian National Congress “Humans and Medicines” [in Russian], Moscow (2002). P. 457.
I. A. Bakker-Woudenberg, A. F. Lokerse, M. T. Kate, et al., Eur. J. Clin. Microbiol. Infect. Dis., 12(1), 61 – 67 (1993).
N. Van Rooijen, Adv. Exp. Med. Biol., 355(1), 69 – 74 (1994).
I. M. Bushmakina, V. K. Matus, M. A. Martynova, et al., Novosti Mediko-Biologicheskikh Nauk, No. 2, 110 – 114 (2004).
V. K. Matus, G. L. Gurevich, S. V. Konev, et al., Vestsi NAN Belarusi Ser. Biyal. Navuk., No. 1, 131 – 141 (2000).
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 43, No. 4, pp. 41 – 43, April, 2009.
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Bushmakina, I.M., Drozdova, N.I., Golenko, N.S. et al. Preparation of a liposomal form of butaminophen by mechanical dispersion. Pharm Chem J 43, 219–221 (2009). https://doi.org/10.1007/s11094-009-0269-0
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DOI: https://doi.org/10.1007/s11094-009-0269-0