We report here the use of an electrochemical method to simplify and reduce the number of stages in the chemical synthesis of Anesthesin (the ethyl ester of p-aminobenzoic acid) from p-nitrotoluene. Methods for electrolysis and product extraction are described. The yields per unit current of the intermediate product p-nitrobenzoic acid and the end product Anesthesin on graphite electrodes increased with increases in the starting substance concentrations, and yields were 98% and 99% respectively in 0.4-M solutions.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 43, No. 4, pp. 44 – 47, April, 2009.
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Magomedova, Z.M., Khidirov, S.S. Use of an electrochemical method in the synthesis of anesthesin from p-nitrotoluene. Pharm Chem J 43, 222–225 (2009). https://doi.org/10.1007/s11094-009-0266-3
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DOI: https://doi.org/10.1007/s11094-009-0266-3