Previously unreported platinum tetrachloride derivatives have been synthesized via the interaction between dipotassium- and disodiumhexachloroplatinates with substituted amides of nicotinic and isonicotinic acid. The synthesized compounds exhibit low general toxicity and show high antimetastatic activity with respect to experimental melanoma B-16 and Lewis lung carcinoma strains.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Explore related subjects
Discover the latest articles and news from researchers in related subjects, suggested using machine learning.References
K. R. Harrap, in: Fifth Int. Congress of Anti-Cancer Chemotherapy, Abstract, Paris (1995).
Y. P. Ho, S. C. Au Gerig, and K. K. To, Med. Res. Rev., No. 23, 633 (2003).
R. B. Ciccarelli, M. J. Solomon, and A. Varshavsky, Biochemistry, No. 24, 7533 (1985).
N. N. Zheligovskaya and E. P. Krasovskaya, RF Pat. No. 1,137,698.
N. N. Zheligovskaya, M. Ya. Mel’nikov, V. G. Silaev, and V. A. Trofimov, RF Pat. No. 2,151,740.
I. I. Chernyaev and N. N. Krasovskaya, Neorg. Khim., 3, 2025 (1958).
A. Sigel and H. Sigel, Metal Ions in Biological Systems, Marcel Dekker Inc., New York (1996).
J. Reedijk, Chem. Commun., 801 (1996).
Russian Drug Registry, Encyclopedia of Drugs, 14 Ed. (2006), p. 567.
Russian Drug Registry, Encyclopedia of Drugs, 14 Ed. (2006), p. 442.
Russian Drug Registry, Encyclopedia of Drugs, 14 Ed. (2006), p. 318.
V. P. Reutov, Usp. Biol. Khim., 35, 189 – 228 (1995).
F. V. De Feudus, Drugs Today, No. 25, 115 (1989).
A. R. Galla, Angew. Chem. Int. Ed. Engl., No. 32, 378 (1993).
B. S. Fedorov, N. I. Golovina, M. A. Fadeev, et al., Izv. Akad. Nauk, Ser. Khim., 527 (1998) [Engl. transl. Russ. Chem. Bull., 48, 1584 (1999)].
B. S. Fedorov, N. I. Golovina, M. A. Fadeev, et al., Izv. Akad. Nauk, Ser. Khim., 499 (2001) [Engl. transl. Russ. Chem. Bull., 50, 520 (2001)].
B. S. Fedorov, M. A. Fadeev, V. V. Arakcheeva, and A. B. Eremeev, RF Pat. No. 2,147,301.
B. S. Fedorov, M. A. Fadeev, G. I. Kozub, et al., RF Pat. No. 2,241,713.
B. S. Fedorov, M. A. Fadeev, G. I. Kozub, et al., RF Pat. No. 2,245,328.
R. U. Khabriev, ed., Handbook of Experimental (Preclinical) Study of New Drugs [in Russian], Moscow (2005).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 43, No. 3, pp. 12 – 16, March, 2009.
Rights and permissions
About this article
Cite this article
Fedorov, B.S., Fadeev, M.A., Kozub, G.I. et al. Synthesis and antimetastatic activity of metal complexes based on substituted pyridinecarboxylic acid amides and platinum tetrachloride. Pharm Chem J 43, 134–138 (2009). https://doi.org/10.1007/s11094-009-0256-5
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11094-009-0256-5