The pharmacokinetics of acetaminophen in two medicinal forms, tablets and capsules, have been studied in healthy volunteers after single peroral administration at a dose of 500 mg under usual living conditions and during long-term space flight. The rate of drug absorption from tablets decreases significantly whereas the relative bioavailability increases substantially under microgravity conditions (compared with usual conditions). For the encapsulated medicinal form, the time of absorption decreases statistically reliably and the half-elimination time, the average retention time, and the distribution volume increase considerably whereas the bioavailability changes insignificantly.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 43, No. 3, pp. 8 – 11, March, 2009.
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Kovachevich, I.V., Kondratenko, S.N., Starodubtsev, A.K. et al. Pharmacokinetics of acetaminophen administered in tablets and capsules under long-term space flight conditions. Pharm Chem J 43, 130–133 (2009). https://doi.org/10.1007/s11094-009-0255-6
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DOI: https://doi.org/10.1007/s11094-009-0255-6