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Comparison of the cytostatic effects of the gemcitabine preparations Gemcitera and Gemzar

  • Molecular-Biological Problems of Drug Design and Mechanism of Drug Action
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Pharmaceutical Chemistry Journal Aims and scope

Cytostatic effects of Gemzar and Gemcitera, drugs containing gemcitabine as the active substance, have been studied using cell cultures of normal rat fibroblasts, MCF-7 (human breast cancer), and HeLa (cervical cancer) as alternative models. Both drugs exhibited high cytostatic activity. With respect to their sensitivity to Gemzar and Gemcitera, the model cells can be ordered as follows: HeLa < MCF-7 < fibroblasts. Gemcitera produced significant dose-dependent cytostatic effects on MCF-7 and HeLa cells, being comparable in this respect to the antitumor action of the reference drug Gemzar.

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Authors and Affiliations

  1. Sechenov Medical Academy, Moscow, Russia

    G. N. Gil’deeva

  2. State Medical University, Moscow, Russia

    A. V. Semeikin

Authors
  1. G. N. Gil’deeva
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  2. A. V. Semeikin
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 43, No. 2, pp. 11–14, February, 2009.

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Gil’deeva, G.N., Semeikin, A.V. Comparison of the cytostatic effects of the gemcitabine preparations Gemcitera and Gemzar. Pharm Chem J 43, 81–83 (2009). https://doi.org/10.1007/s11094-009-0247-6

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  • DOI: https://doi.org/10.1007/s11094-009-0247-6

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