Alkylation of a number of α-amino acids, as well as β-phenyl-β-alanine and γ-aminobutyric acid, with the hydrochlorides of p-substituted β-diethylaminopropiophenones resulted in the synthesis of N-[β-(p-substituted benzoyl)ethyl]cysteine, threonine, methionine, isoleucine, asparagine, and glutamine, along with β-phenyl-β-alanine, and γ-aminobutyric acid. The anti-inflammatory activities of the resulting compounds were studied; several of them had moderate anti-inflammatory activity.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 43, No. 1, pp. 14–16, January, 2009.
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Agababyan, A.G., Gevorgyan, G.A., Tumadzhyan, A.E. et al. Synthesis and anti-inflammatory, analgesic, and antipyretic activities of N-[β-(p-substituted benzoyl)ethyl]amino acids. Pharm Chem J 43, 13–15 (2009). https://doi.org/10.1007/s11094-009-0239-6
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DOI: https://doi.org/10.1007/s11094-009-0239-6