Series of 1,4-disubstituted piperazine and of N,N-disubstituted ethylenediamine having the 2,3-diphenyl- 1H-indole-5-carbonyl group as one of the two substituents were prepared. Compounds 3, 4, 11, 15 – 17, and 20 – 22 were tested for analgesic activity. After ip administration all compounds induced significant visceral antinociceptive activities where acetic acid-induced writhing was significantly reduced by all compounds.
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El-Nezhawy, A.O.H., El-Naem, S.I., Galal, S.A. et al. Synthesis and analgesic activity of (2,3-diphenyl-1H-indol-5-YL)piperazin-1-yl methanone derivatives. Pharm Chem J 43, 25–29 (2009). https://doi.org/10.1007/s11094-009-0234-y
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DOI: https://doi.org/10.1007/s11094-009-0234-y