The conditions for preparing 14α-hydroxyandrostenedione - an intermediate in the synthesis of highly active gestagens - using the fungus Curvularia lunata CBE with an increased steroid substrate load of 5 g/liter in the presence of methylcyclodextrin were identified. The microbiological method of introducing 14α-hydroxy groups into the androstane structure has significant advantages over chemical approaches from the technical and ecological points of view and for obtaining a higher yield.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 43, No. 1, pp. 37–40, January, 2009.
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Yaderets, V.V., Andryushina, V.A., Voishvillo, N.E. et al. Studies of synthesis routes for biologically active 14α-hydroxylated steroids. Pharm Chem J 43, 55–58 (2009). https://doi.org/10.1007/s11094-009-0229-8
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DOI: https://doi.org/10.1007/s11094-009-0229-8