The reaction of 2-methyl-1-(p-tolyl)propanol-2 with N-alkyl-, N-benzyl-, and N-arylcyanacetamides was used to synthesize 2-(3,3,7-trimethyl-3,4-dihydroisoquinolyl-1)ethanoic acid amides. Investigations showed that tertiary amides formed from cyclic amines (morpholine, piperidine, etc.) had hypertensive actions, while all the other amides had hypotensive effects). The most active compound decreased arterial pressure by 46 mmHg and the duration of action was 90 min.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 43, No. 1, pp. 5–7, January, 2009.
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Limanskii, E.S., Mikhailovskii, A.G., Syropyatov, B.Y. et al. Synthesis of amides of 2-(3,3,7-trimethyl-3,4-dihydroisoquinolyl-1)ethanoic acid and their effects on arterial blood pressure. Pharm Chem J 43, 4–6 (2009). https://doi.org/10.1007/s11094-009-0221-3
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DOI: https://doi.org/10.1007/s11094-009-0221-3