Antiviral agents were sought by using ethyl esters of 2-R-4-quinolinecarboxylic acids to synthesize the corresponding aryl (heteryl) hydrazides. 2-Methyl-4-quinolinecarboxylic acid hydrazide was used to synthesize vinylogs containing a nitro group in the substituent. The resulting compounds were tested for antiviral activity against ECHO virus type 6.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 42, No. 10, pp. 21–23, October, 2008.
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Zemtsova, M.N., Zimichev, A.V., Trakhtenberg, P.L. et al. Synthesis and antiviral activity of 4-quinolinecarboxylic acid hydrazides. Pharm Chem J 42, 571–573 (2008). https://doi.org/10.1007/s11094-009-0187-1
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DOI: https://doi.org/10.1007/s11094-009-0187-1