Quantitative determination of the total content of flavonoids in Flavozid and Immunoflazid syrups

New syrup compositions Flavozid and Immunoflazid that contain 2% Proteflazid (ethanol extract of wild Deschampsia caespitosa L. and Calamagrostis epigeios L.) have been developed. The total content of flavonoids in both syrups is of the level of 4–6 µg/mL, which complicates the development of an analytical method. A new method for quantitative determination of flavonoids in the aforementioned syrups has been developed on the basis of differential UV spectrophotometry of their complexes with aluminum chloride. The proposed method is introduced into the Manufacturer's Pharmacopoeic Article for the syrups.

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Correspondence to O. V. Vishnevskii.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 42, No. 9, pp. 40–42, September, 2008.

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Vishnevskii, O.V., Atamanyuk, V.P. Quantitative determination of the total content of flavonoids in Flavozid and Immunoflazid syrups. Pharm Chem J 42, 536–538 (2008). https://doi.org/10.1007/s11094-009-0176-4

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Keywords

  • Flavonoid
  • Quercetin
  • Rutin
  • Glacial Acetic Acid
  • Aluminum Chloride