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Synthesis and rheological activity of new 1,2,4-triazole derivatives

  • Molecular-Biological Problems of Drug Design and Mechanism of Drug Action
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Pharmaceutical Chemistry Journal Aims and scope

Reactions of 3,5-dibromo-1,2,4-triazoles containing thietane or thietane-1,1-dioxide with thioglycolic acid yielded 2-[1-(thietanyl-3)-or 2-[1-(1,1-dioxothietanyl-3)-3-bromo-1,2,4-triazolyl-5-thio]acetic acids. Their salts have also been synthesized via reactions with amines and alkalis. Evaluation of the rheological properties showed that some of the synthesized compounds exhibited antiaggregant activity with respect to erythrocytes that was comparable with the effect of pentoxifylline.

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Authors and Affiliations

  1. Bashkir State Medical University, Ufa, Bashkortostan, Russia

    E. E. Klen, F. A. Khaliullin, A. A. Spasov, N. N. Makarova, L. F. Bagautdinova & L. V. Naumenko

  2. Volgograd State Medical University, Volgograd, Russia

    E. E. Klen, F. A. Khaliullin, A. A. Spasov, N. N. Makarova, L. F. Bagautdinova & L. V. Naumenko

Authors
  1. E. E. Klen
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  2. F. A. Khaliullin
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  3. A. A. Spasov
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  4. N. N. Makarova
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  5. L. F. Bagautdinova
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  6. L. V. Naumenko
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 42, No. 9, pp. 15–17, September, 2008.

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Klen, E.E., Khaliullin, F.A., Spasov, A.A. et al. Synthesis and rheological activity of new 1,2,4-triazole derivatives. Pharm Chem J 42, 510–512 (2008). https://doi.org/10.1007/s11094-009-0171-9

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  • DOI: https://doi.org/10.1007/s11094-009-0171-9

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