A series of 3,4-dihydropyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4-ones were synthesized by the reaction of ethyl 3-alkyl(aryl)carboxamidothieno[2,3-b]pyridine-2-carboxylates with aliphatic amines. The starting carboxamides were obtained via the reaction of ethyl 3-aminothieno[2,3-b]pyridine-2-carboxylate with acid chlorides. It is established that the synthesized pyridothienopyrimidinones possess antistaphylococcal activity.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
J. M. Quintela, C. Peinador, C. Veiga, et al., Bioorg. Med. Chem., 6, 1911–1925 (1988).
E. Bousquet, G. Romeo, F. Guerrera, et al., Farmaco, 40, 869–874 (1985).
M. Z. A. Bard, S. A. Mahgoub, F. F. Abdel-Latif, et al., Phosphorus, Sulfur and Silicon, 55, 175–183 (1991).
A. E. Abdel-Rahman, E. A. Bakhite, and E. A. Al-Taifi, J. Chin. Chem. Soc., 49, 223–231 (2002).
V. P. Litvinov, V. V. Dotsenko, and S. G. Krivokolysko, Chemistry of Thienopyridines and Related Systems [in Russian], Nauka, Moscow (2006), pp. 72–102.
E. A. Kaigorodova, L. D. Konyushkin, M. E. Niyazymbetov, et al., Izd. Akad. Nauk, Ser. Khim., 12, 2215–2219 (1994).
Author information
Authors and Affiliations
Additional information
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 42, No. 9, pp. 37–39, September, 2008.
Rights and permissions
About this article
Cite this article
Kostenko, E.S., Kaigorodova, E.A., Serdyuchenko, I.V. et al. Synthesis and antibacterial activity of 3,4-dihyhdropyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4-ones. Pharm Chem J 42, 533–535 (2008). https://doi.org/10.1007/s11094-009-0168-4
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11094-009-0168-4