Skip to main content
SpringerLink
Log in

Antitumor activity of substituted methylglyoxal bisthiosemicarbazones and their copper(II) chelates

  • Molecular-Biological Problems of Drug Design and Mechanism of Drug Action
  • Published:
Pharmaceutical Chemistry Journal Aims and scope

A series of new bisthiosemicarbazones of methylglyoxal and their copper(II) complexes were synthesized. Evidence of antitumor properties of some products combined with low toxicity shows that further searching for antitumor agents in this group of compounds may be promising.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. H. G. Petering and G. I. Van Giessen, Biochemistry of Copper, Academic Press, New York (1966), pp. 197–209.

    Google Scholar 

  2. J. A. Crim and H. G. Petering, Cancer Res., 27, 1278–1285 (1967).

    PubMed  CAS  Google Scholar 

  3. E. R. Dilanyan, T. R. Ovsepyan, F. G. Arsenyan, et al., Khim.-farm. Zh., 18, No. 7, 835–839 (1984).

    CAS  Google Scholar 

  4. E. R. Dilanyan, T. R. Ovsepyan, F. G. Arsenyan, et al., Khim.-farm. Zh., 18, No. 8, 927–931 (1984).

    CAS  Google Scholar 

  5. E. R. Dilanyan, T. R. Ovsepyan, F. G. Arsenyan, et al., Khim.-farm. Zh., 23, No. 5, 602–605 (1989).

    CAS  Google Scholar 

  6. E. R. Dilanyan, T. R. Ovsepyan, G. M. Stepanyan, et al., Khim.-farm. Zh., 34, No. 8, 16–17 (2000).

    Google Scholar 

  7. T. R. Ovsepyan, E. R. Dilanyan, N. O. Stepanyan, et al., Arm. Khim. Zh., 37, No. 4, 249–253 (1984).

    CAS  Google Scholar 

  8. H. G. Petering, H. H. Buskirk, and G. E. Underwood, Cancer Res., 24, No. 3, 367–372 (1964).

    PubMed  CAS  Google Scholar 

  9. Ya. I. Korenman, Extraction of Phenols [in Russian], Gorky (1973).

  10. G. Bahr and E. Hess, Z. Anorg. Allg. Chem., 268, No. 6, 351–363 (1952).

    Article  CAS  Google Scholar 

  11. G. N. Pershin, Methods of Experimental Chemotherapy [in Russian], Medgiz, Moscow (1971).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Mndzhoyan Institute of Fine Organic Chemistry, National Academy of Sciences of Armenia, Yerevan, Armenia

    E. R. Dilanyan, T. R. Ovsepyan, F. G. Arsenyan, G. M. Stepanyan & B. T. Garibdzhanyan

Authors
  1. E. R. Dilanyan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. R. Ovsepyan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. F. G. Arsenyan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G. M. Stepanyan
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. B. T. Garibdzhanyan
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 42, No. 9, pp. 9–11, September, 2008.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dilanyan, E.R., Ovsepyan, T.R., Arsenyan, F.G. et al. Antitumor activity of substituted methylglyoxal bisthiosemicarbazones and their copper(II) chelates. Pharm Chem J 42, 504–506 (2008). https://doi.org/10.1007/s11094-009-0162-x

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-009-0162-x

Keywords

Search

Navigation