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Indirect determination of N-acetyltransferase activity using ammonium metavanadate for evaluating isoniazide excretion with human urine

  • Structure of Chemical Compounds, Methods of Analysis and Process Control
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Pharmaceutical Chemistry Journal Aims and scope

Optimum conditions for the analytical determination of isonicotinic acid hydrazide in urine using ammonium metavanadate are established. Anoninvasive method for the indirect determination of N-acetyltransferase activity in human hepatocytes that is based on measurement of the isoniazide fraction excreted with urine for 6 h is proposed.

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Authors and Affiliations

  1. Kazan State Technological University, Kazan, Tatarstan, Russia

    S. Yu. Garmonov, N. S. Shilova, A. V. Yakoleva & R. A. Yusupov

Authors
  1. S. Yu. Garmonov
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  2. N. S. Shilova
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  3. A. V. Yakoleva
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  4. R. A. Yusupov
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 42, No. 8, pp. 49–53, August, 2008.

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Garmonov, S.Y., Shilova, N.S., Yakoleva, A.V. et al. Indirect determination of N-acetyltransferase activity using ammonium metavanadate for evaluating isoniazide excretion with human urine. Pharm Chem J 42, 488–492 (2008). https://doi.org/10.1007/s11094-008-0157-z

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  • DOI: https://doi.org/10.1007/s11094-008-0157-z

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