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Pharmaceutical Chemistry Journal

, Volume 42, Issue 8, pp 479–480 | Cite as

Gas-chromatographic determination of methylmethanesulfonate in anti-arthrosis tablets

  • D. V. Kompantsev
  • L. S. Ushakova
  • I. V. Grigoryan
  • L. I. Shcherbakova
  • E. V. Kompantseva
Structure of Chemical Compounds, Methods of Analysis and Process Control

New tablets possessing anti-arthrosis properties have been created. The basic active agents in this preparation are glucosamine sulfate and methylmethanesulfonate (mesylmethane, MM). It is established that glucosamine in combination with willow-bark extract exhibits more pronounced specific activity. It is suggested to determine the quantitative content of MM by a gas chromatographic (GC) method with the use of a working reference sample. The validation has been carried out. The metrological performance of the proposed method is characterized. The calculated validation parameters confirmed the applicability of GC to the quantification of MM in the anti-arthrosis tablets.

Keywords

Glucosamine Metrological Characteristic Quantitative Content Glucosamine Sulfate Methylmethanesulfonate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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    K. Doerfeel, Statistics in Analytical Chemistry, VCH, Weinheim, FRG (1987).Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2008

Authors and Affiliations

  • D. V. Kompantsev
    • 1
  • L. S. Ushakova
    • 1
  • I. V. Grigoryan
    • 1
  • L. I. Shcherbakova
    • 1
  • E. V. Kompantseva
    • 1
  1. 1.Pyatigorsk State Pharmaceutical AcademyPyatigorskRussia

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