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Micro-Preparative Chromatographic Separation of Naproxen Enantiomers

  • Structure of Chemical Compounds, Methods of Analysis and Process Control
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Pharmaceutical Chemistry Journal Aims and scope

Chromatographic micro-preparative separation of a racemic mixture of naproxen enantiomers using a chiral stationary phase of Chiralcel OJ-H has been studied. Optimum conditions for the separation have been found. It is shown that a special fraction collection scheme involving an intermediate region between the minimum between peaks and the maximum of the second peak should be used for the simultaneous recovery of both enantiomers. In this case, S-(0.12 mg) and R-naproxen (0.12 mg) with a purity of up to 99.4 and 94.5%, respectively, can be isolated in one run using a standard analytical column.

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Authors and Affiliations

  1. Institute of Technical Chemistry, Ural Branch, Russian Academy of Sciences, Perm, Russia

    L. D. Asnin

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  1. L. D. Asnin
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 42, No. 7, pp. 54–56, July, 2008.

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Asnin, L.D. Micro-Preparative Chromatographic Separation of Naproxen Enantiomers. Pharm Chem J 42, 435–437 (2008). https://doi.org/10.1007/s11094-008-0145-3

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  • DOI: https://doi.org/10.1007/s11094-008-0145-3

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