Experimental Adaptation of Staphylococcus Aureus to Sulfuryl Derivatives of Benzazolides

A state of pre-adaptation to highly toxic doses of sulfuryl derivatives of benzimidazole and benzotriazole was developed in Staphylococcus aureus species by treating them with non-toxic doses of these compounds. Pre-treatment of S. aureus with the starting benzazolides (benzimidazole and benzotriazole) also created the pre-adaptation to their sulfuryl derivatives. Experiments on cross-pre-adaptation where the pre-adaptation to sulfuryl derivatives of benzazolides was created by the action of non-toxic doses of benzotriazole and vice versa showed that the planar structures of the double ring of benzazolide plays a key role in activation of the repair systems of S. aureus. Mathematical analysis revealed a high nonlinear correlation between the ability of a compound to create the state of pre-adaptation in S. aureus culture on one hand and the physical and chemical properties such as the lipophilicity, molecular weight and volume, and hydration energy on the other.