Pharmaceutical Chemistry Journal

, Volume 42, Issue 2, pp 95–97

Applications of extraction freezing in pharmacology and biochemistry

  • V. N. Bekhterev
  • S. N. Gavrilova
  • E. V. Koshkareva
Drug Synthesis Methods and Production Technologies

DOI: 10.1007/s11094-008-0067-0

Cite this article as:
Bekhterev, V.N., Gavrilova, S.N. & Koshkareva, E.V. Pharm Chem J (2008) 42: 95. doi:10.1007/s11094-008-0067-0


A method for extracting organic substances from aqueous media by combining extraction with freezing is described. The method allows hydrophilic extractants to be used. Analysis of ionogenic organic compounds provides an example demonstrating the wide potential of this method. A method for the analysis of 1,4-benzodiazepines in urine was developed. As compared with existing methods, the sample preparation procedure described here is significantly quicker and simpler, and requires virtually no laboratory equipment.

Copyright information

© Springer Science+Business Media, Inc. 2008

Authors and Affiliations

  • V. N. Bekhterev
    • 1
  • S. N. Gavrilova
    • 2
  • E. V. Koshkareva
    • 3
  1. 1.Sochi State University of Tourism and RecreationSochiRussia
  2. 2.Forensic Medicine BureauSochiRussia
  3. 3.Sochi DepartmentState Krasnodar Forensic LaboratorySochiRussia

Personalised recommendations