Pharmaceutical Chemistry Journal

, Volume 42, Issue 2, pp 95–97 | Cite as

Applications of extraction freezing in pharmacology and biochemistry

  • V. N. Bekhterev
  • S. N. Gavrilova
  • E. V. Koshkareva
Drug Synthesis Methods and Production Technologies

Abstract

A method for extracting organic substances from aqueous media by combining extraction with freezing is described. The method allows hydrophilic extractants to be used. Analysis of ionogenic organic compounds provides an example demonstrating the wide potential of this method. A method for the analysis of 1,4-benzodiazepines in urine was developed. As compared with existing methods, the sample preparation procedure described here is significantly quicker and simpler, and requires virtually no laboratory equipment.

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References

  1. 1.
    S. K. Eremin, Analysis of Narcotic Substances: Handbook for the Chemical-Toxicological Analysis of Narcotics and Other Intoxicating Substances [in Russian], B. N. Izotov (ed.), Mysl', Moscow (1993).Google Scholar
  2. 2.
    V. N. Bekhterev, A Means of Extracting Organic Compounds from Aqueous Media by Extraction Combined with Freezing [in Russian], Russian Patent No. 2005112810, 27 April 2005.Google Scholar
  3. 3.
    A. A. Rusinova, Yu. M. Polezhaev, and A. I. Matern, Analit. Kontr., No. 4, 4–10 (1999).Google Scholar
  4. 4.
    R. R. Krasnova, Methods of Detecting and Estimating Benzodiazepines in Biological Materials. A Practical Guide [in Russian], RTs Sudebno-meditsinskii Ékspertizy, Moscow (2000).Google Scholar
  5. 5.
    Methods for Estimating Microquantities of Pesticides in Food and Fodder Products and the Environment [in Russian], M. A. Klisenko, A. A. Kalinina, K. F. Novikova, et al. (eds.), Kolos, Moscow (1992), Vol. 1.Google Scholar
  6. 6.
    Methods for Estimating Microquantities of Pesticides in Food and Fodder Products and Environmental Materials: A Handbook [in Russian], M. A. Klisenko, A. A. Kalinina, K. F. Novikova, et al. (eds.), Agroprimizdat, Moscow (1992), Vol. 2.Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2008

Authors and Affiliations

  • V. N. Bekhterev
    • 1
  • S. N. Gavrilova
    • 2
  • E. V. Koshkareva
    • 3
  1. 1.Sochi State University of Tourism and RecreationSochiRussia
  2. 2.Forensic Medicine BureauSochiRussia
  3. 3.Sochi DepartmentState Krasnodar Forensic LaboratorySochiRussia

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