Skip to main content
SpringerLink
Log in

Synthesis and tuberculostatic activity of N-aminoacetic acid hydrazides and acylhydrazides based on ephedrine alkaloids

  • Published:
Pharmaceutical Chemistry Journal Aims and scope

Abstract

N-Alkaloid acetic acid hydrazides have been obtained by the hydrazinolysis of morpholones, and the acylation reactions of these hydrazides have been carried out. Screening investigations of the synthesized derivatives in vitro and in vivo have revealed, for the first time among the ephedrine alkaloids, a promising compound (N-d-pseudoephedrinylacetic acid hydrazide) possessing pronounced antituberculosis activity comparable with that of isoniazid.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. K. K. Medne, Proceedings of the Meeting on the Current Problems in the Search for and Characterization of New Drugs [in Russian], Riga (1959), p. 53.

  2. I. S. Berdinskii, L. V. Sennitskaya, and L. F. Chereshneva, Khim.-Farm. Zh., 7(1), 10–14 (1973).

    CAS  Google Scholar 

  3. C. Marcu, V. Bratu, M. Manuckian, et. al., Farmacia (RPR), 11(10), 617–623 (1963).

    CAS  Google Scholar 

  4. V. P. Chernykh, N. N. Valyashko, T. S. Dzhan-Temirova, et al., Khim.-Farm. Zh., 6(7), 8–10 (1972).

    CAS  Google Scholar 

  5. K. K. Medne, Izv. Akad. Nauk. Latv. SSR, No. 12, 119–123 (1967).

  6. M. D. Mashkovskii, Drugs [in Russian], Novaya Volna, Moscow (2001), pp. 306–309.

    Google Scholar 

  7. O. A. Nurkenov 1, A. M. Gazaliev, I. V. Kulakov, et al., Zh. Obshch. Khim., 67(7), 1222 (1997).

    Google Scholar 

  8. O. A. Nurkenov 1, A. M. Gazaliev, I. V. Kulakov, et al., Zh. Obshch. Khim., 68(8), 1320–1321 (1997).

    Google Scholar 

  9. O. A. Nurkenov 1, I. V. Kulakov, and A. M. Gazaliev, Zh. Obshch. Khim., 69(10), 1743–1747 (1999).

    Google Scholar 

  10. G. N. Pershin, Methods of Experimental Chemotherapy [in Russian], Meditsina, Moscow (1971), p. 539.

    Google Scholar 

  11. Tuberculosis: Methods of Experimental Chemotherapy [in Russian], O. O. Makeeva and G. N. Pershin (eds.), Meditsina, Moscow (1971), pp. 166–185.

    Google Scholar 

  12. V. B. Prozorovskii, Practical Guide on the Accelerated Determination of Average Effective doses and Concentrations of Bilogicvally Active Substances [in Russian], St. Petersburg (1992).

Download references

Author information

Authors and Affiliations

  1. Institute of Organic Synthesis and Carbochemistry, Karaganda, Republic of Kazakhstan

    I. V. Kulakov, O. A. Nurkenov & M. A. Gazalieva

  2. Karaganda State Medical Academy, Karaganda, Republic of Kazakhstan

    S. K. Zhaugasheva & Zh. O. Isakova

Authors
  1. I. V. Kulakov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. O. A. Nurkenov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. A. Gazalieva
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. K. Zhaugasheva
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Zh. O. Isakova
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to I. V. Kulakov.

Additional information

__________

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 41, No. 11, pp. 52–56, November, 2007.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kulakov, I.V., Nurkenov, O.A., Gazalieva, M.A. et al. Synthesis and tuberculostatic activity of N-aminoacetic acid hydrazides and acylhydrazides based on ephedrine alkaloids. Pharm Chem J 41, 620–624 (2007). https://doi.org/10.1007/s11094-008-0020-2

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-008-0020-2

Keywords

Search

Navigation