Abstract
The distribution of sodium perrenate (Na188ReO4) in the organism of intact mice has been studied. It is shown that the behavior of Na188ReO4 in the organism depends on the method of administration. In particular, the level of drug accumulation in the majority of organs and tissues is lower upon intraperitoneal administration than after intravenous introduction. The elimination of the preparation from the organs and tissues proceeds at a higher rate upon intraperitoneal administration than after intravenous injections. Selective accumulation of Na188ReO4 at higher concentrations takes place in the thyroid gland and stomach. These results can be useful in determining the pharmacokinetic characteristics of osteotropic radiopharmaceuticals for the estimation of their functional value for intratissue radionuclide therapy of bone metastases.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 41, No. 11, pp. 7–10, November, 2007.
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Petriev, V.M., Smoryzanova, O.A. & Skvortsov, V.G. Distribution of sodium perrenate in intact mice. Pharm Chem J 41, 573–576 (2007). https://doi.org/10.1007/s11094-008-0018-9
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DOI: https://doi.org/10.1007/s11094-008-0018-9