Skip to main content
SpringerLink
Log in

Pharmacokinetics of curcuminoids contained in the phytopreparation arthroflex

  • Molecular-Biological Problems of Drug Design and Mechanism of Drug Action
  • Published:
Pharmaceutical Chemistry Journal Aims and scope

Abstract

Curcuminoids are the main active components in the extract of curcuma roots (Curcuma longa), which is widely used as an anti-inflammatory agent. We have studied the bioavailability and determined the pharmacokinetic parameters of curcuminoids contained in the complex phytopreparation Arthroflex studied experimentally in vitro and in vivo. The release of curcuminoids from Arthroflex into a nonconventional biphase system modeling conditions in the gastrointestinal tract was investigated in vitro and the dissolution rate constants were calculated. The pharmacokinetics of curcuminoids was investigated in vivo. It was established that curcumin in the initial form was missing from the blood plasma, and only two metabolites of curcuminoids were found by thin layer chromatography. The pharmacokinetic parameters of the major metabolite were determined.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. P. R. Holt, S. Katz, and R. Kirshoff, Digest. Dis. Sci., 50(11), 2191–2193 (2005).

    Article  PubMed  Google Scholar 

  2. C. R. Ireson, D. J. Jones, S. Orr, et al., Cancer Epidemiol. Biomarkers Prev., 11(1), 105–111 (2002).

    PubMed  CAS  Google Scholar 

  3. Y. Kiso, Y. Suzuki, N. Watanabe, et al., Planta Med., 49, 185–187 (1983).

    Article  CAS  Google Scholar 

  4. E. J. Park, C. H. Jeon, G. Ko, et al., J. Pharm. Pharmacol., 52, 437–440 (2000).

    Article  PubMed  CAS  Google Scholar 

  5. V. K. Piotrovskii, Farmakol. Toksikol., 49(5), 118–127 (1986).

    PubMed  CAS  Google Scholar 

  6. V. Pillay and R. Fassihi, J. Pharm. Sci., 88, 843–851 (1999).

    Article  PubMed  CAS  Google Scholar 

  7. M. V. Karlina, A. Yu. Eshenko, O. N. Pozharitskaya, and G. I. D’yachuk, Proceedings of the 8th Int. Congr. PHYTOPHARM-2004 (June 21–23, 2004, Mikkeli, Finland), pp. 665–669.

  8. Min-Hsiug Pan, Tsang-Miao Huang, and Jen-Kun Lin, Drug Metab. Dispos., 27, 486–494 (1999).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Inter-Regional Center “Adaptogen”, St. Petersburg, Russia

    M. V. Karlina, O. N. Pozharitskaya & S. A. Ivanova

Authors
  1. M. V. Karlina
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. O. N. Pozharitskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. A. Ivanova
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

__________

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 41, No. 10, pp. 3–5, October, 2007.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Karlina, M.V., Pozharitskaya, O.N. & Ivanova, S.A. Pharmacokinetics of curcuminoids contained in the phytopreparation arthroflex. Pharm Chem J 41, 513–515 (2007). https://doi.org/10.1007/s11094-008-0001-5

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-008-0001-5

Keywords

Search

Navigation