Skip to main content
Log in

Anti-inflammatory and antiulcer activity of the conjugate of penta-O-acetylglycyrrhizic acid with methionine methyl ester

  • Search for New Drugs
  • Published:
Pharmaceutical Chemistry Journal Aims and scope

Abstract

The pharmacological properties of the conjugate of penta-O-acetylglycyrrhizic acid with methionine methyl ester were studied. The antiinflammatory (AI) activity was estimated using mouse and rat inflammation models induced by formalin, thermal action, Difco agar, trypsin, histamine, and bradykinin compared with glycyrrhizic acid (I), butadione, and prednisolone. It was found that this compound has distinct AI activity that exceeds the activity of I. The AI activity of the conjugate was combined with high antiulcer (AU) activity that exceeded that of I. The conjugate healed both acute (histamine and serotonin) and chronic (reserpine and acetic acid) ulcers of rat stomach mucous lining and had low toxicity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. G. A. Tolstikov, L. A. Baltina, E. E. Shul’ts, and A. G. Pokrovskii, Bioorg. Khim., 23(9), 691–709 (1997).

    PubMed  CAS  Google Scholar 

  2. L. A. Baltina, V. A. Davydova, I. G. Chikaeva, et al., Khim.-farm. Zh., 22(6), 694–697 (1988).

    CAS  Google Scholar 

  3. V. A. Davydova, F. S. Zarudii, L. A. Baltina, et al., Khim.-Farm. Zh., 29(1), 41–44 (1995).

    CAS  Google Scholar 

  4. M. L. Belen’kii, Elements of Quantitative Estimation of Pharmacological effects [in Russian], Leningrad (1963), p. 152.

  5. F. P. Trinus, N. A. Mokhort, and B. M. Klebanov, Nonsteroidal Anti-inflammatory Drugs [in Russian], Zdorov’ya, Kiev (1975), pp. 204–216.

    Google Scholar 

  6. L. A. Baltina, R. M. Kondratenko, S. R. Mustafina, et al., Khim.-farm. Zh., 35(1), 38–41 (2001).

    Google Scholar 

  7. S. V. Anichkov and I. S. Zavodskaya, Pharmacotherapy of Ulcerous Diseases [in Russian], Meditsina, Leningrad (1965), p. 187.

    Google Scholar 

  8. A. A. Nikulin and S. I. Budantseva, Farmakol. Toksikol., 36(5), 564–567 (1973).

    PubMed  CAS  Google Scholar 

  9. I. F. Izmerov, I. V. Sanotskii, and L. L. Sidorov, Toxicometric Parameters of Industrial Poisons for Single Administration [in Russian], Moscow (1977).

Download references

Author information

Authors and Affiliations

Authors

Additional information

__________

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 41, No. 7, pp. 15–19, July, 2007.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kondratenko, R.M., Baltina, L.A., Gromakova, L.S. et al. Anti-inflammatory and antiulcer activity of the conjugate of penta-O-acetylglycyrrhizic acid with methionine methyl ester. Pharm Chem J 41, 357–361 (2007). https://doi.org/10.1007/s11094-007-0081-7

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-007-0081-7

Keywords

Navigation