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Effect of cinazepam administration on the ligand affinity of neuromediator system receptors in rat brain

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Abstract

The influence of single and long-term administration of cinazepam and zopiclon on the affinity of dopamine D1 and D2, serotonin 5-HT1A, cholecystokinin CCK2, and peripheral benzodiazepine receptors to the corresponding ligands in rat brain has been studied. The long-term administration of cinazepam changes the affinity of receptors to radiolabeled ligands to a much lower extent as compared to the administration of zopiclon.

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Authors and Affiliations

  1. Bogatsky Institute of Physical Chemistry, National Academy of Sciences of Ukraine, 65080, Odessa, Ukraine

    S. Yu. Makan, I. A. Boiko, S. P. Smul’skii & S. A. Andronati

Authors
  1. S. Yu. Makan
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  2. I. A. Boiko
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  3. S. P. Smul’skii
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  4. S. A. Andronati
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Correspondence to S. Yu. Makan.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 41, No. 5, pp. 18–21, May, 2007.

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Makan, S.Y., Boiko, I.A., Smul’skii, S.P. et al. Effect of cinazepam administration on the ligand affinity of neuromediator system receptors in rat brain. Pharm Chem J 41, 249–252 (2007). https://doi.org/10.1007/s11094-007-0055-9

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  • DOI: https://doi.org/10.1007/s11094-007-0055-9

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