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Spectrophotometric determination of isonaphthazarin impurity in 1,4-dioxo-2,2,3,3-tetrahydroxy-1,2,3,4-terahydronaphthalene (tetraxolin)

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Abstract

A quantitative spectrophotometric method has been developed for determining the impurity of isonaphthazarin in samples of tetraxolin. The relative error of determination is about 1.0% at a confidence probability of P = 0.95%. The procedure is recommended for the quantitative control of the possible impurity of isonaphthazarin in the parent substance of tetraxolin.

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References

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Authors and Affiliations

  1. Center for Drug Chemistry — All-Russia Research Institute of Pharmaceutical Chemistry, Moscow, Russia

    O. A. Markova & E. V. Degterev

Authors
  1. O. A. Markova
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  2. E. V. Degterev
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 41, No. 1, pp. 38–40, January, 2007.

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Markova, O.A., Degterev, E.V. Spectrophotometric determination of isonaphthazarin impurity in 1,4-dioxo-2,2,3,3-tetrahydroxy-1,2,3,4-terahydronaphthalene (tetraxolin). Pharm Chem J 41, 37–39 (2007). https://doi.org/10.1007/s11094-007-0009-2

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  • DOI: https://doi.org/10.1007/s11094-007-0009-2

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