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Synthesis and pharmacological properties of 2,3,4-triaminopyridine derivatives

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Abstract

A series of 2-chloro-, 2-amino-, and 2-thio-substituted 6-methyl-3-nitro-4-(phenylamino)pyridines have been synthesized via the reduction of 2-amino-derivatives of 6-methyl-3-nitro-4-(phenylamino)pyridines, followed by transformation of the intermediate substituted 2,3,4-triaminopyridines into bicyclic compounds. The results of biological investigations showed that some of the synthesized compounds produce certain effects on the central nervous system of experimental animals.

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Authors and Affiliations

  1. State Scientific Center for Antibiotics, Moscow, Russia

    T. I. Vozyakova, L. M. Alekseeva, V. A. Parshin, M. A. Kalinkina & V. G. Granik

Authors
  1. T. I. Vozyakova
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  2. L. M. Alekseeva
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  3. V. A. Parshin
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  4. M. A. Kalinkina
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  5. V. G. Granik
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 12, pp. 8–12, December, 2006.

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Vozyakova, T.I., Alekseeva, L.M., Parshin, V.A. et al. Synthesis and pharmacological properties of 2,3,4-triaminopyridine derivatives. Pharm Chem J 40, 645–649 (2006). https://doi.org/10.1007/s11094-006-0211-7

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  • DOI: https://doi.org/10.1007/s11094-006-0211-7

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