Antidepressant activity of some phytopharmaceuticals and phenylpropanoids
- 202 Downloads
The antidepressant activity of some phytopreparations and phenylpropanoids was studied in white rats, which were subjected to the desperation test and neuropharmacological tests based on the antagonist activity with respect to reserpine, clofelin, and L-DOPA. The most pronounced effect was exhibited by the extract of Eleutherococcus senticosus, which produced a 56.4% decrease in the immobilization period in rats that was comparable with, albeit somewhat lower than the effect of amitriptyline (73.5%). The antidepressant effects of other phytopreparations decreased in the following order: Rhodiola rosea (53.8%), Echinacea purpurea (49%), and Schizandra chinensis (29.8%). Among phenylpropanoids, the maximum antidepressant effects were produced by syringin and rosavin (49.7% and 29.5%, respectively). The most pronounced antagonism with respect to reserpine was also observed for syringin. The tinctures of Echinacea purpurea and Schizandra chinensis, as well as phenylpropanoid triandrin produced the maximum antidepressant effect in the clofelin-induced depression test. An increase in the stimulating action of L-DOPA was observed upon the administration of rosavin and the tinctures of Schizandra chinensis and Echinacea purpurea.
KeywordsReserpine Antidepressant Activity Silybin Immobilization Time Echinacea Purpurea
Unable to display preview. Download preview PDF.
- 1.V. A. Bykov, G. G. Zapesochnaya, and V. A. Kurkin, Khim.-Farm. Zh., 33(1), 28–32 (1999).Google Scholar
- 2.V. A. Kurkin, N. A. Grinenko, and G. G. Zapesochnaya, Khim. Prir. Soedin., No. 6, 768–771 (1991).Google Scholar
- 3.V. A. Kurkin, Phenylpropanoids: Promising Natural Biologically Active Substances [in Russian], Samara State University, Samara (1996).Google Scholar
- 4.V. A. Kurkin, Pharmacognostics (A Handbook for Students) [in Russian], Ofort, Samara (2004).Google Scholar
- 5.V. A. Kurkin, G. G. Zapesochnaya, E. V. Avdeeva, and V. N. Ezhkov, Phenylpropanoids: Independent Class of Biologically Active Substances [in Russian], Ofort, Samara (2005).Google Scholar
- 6.A. S. Saratikov and E. A. Krasnov, Pink Rhodiola: A Valuable Medicinal Plant (Golden Root) [in Russian], Tomsk (1987).Google Scholar
- 7.S. Ya. Sokolov, V. P. Boiko, V. A. Kurkin, et al., Khim.-Farm. Zh., 24(10), 66–68 (1990).Google Scholar
- 8.R. Bauer, H. Wagner, Echinacea: Handbuch für Artze, Apotheker und andere Naturwissenschaftler, Wissenschaftliche Verlags–geselschaft, Stuttgart (1990).Google Scholar
- 9.H. Wagner, Pharmazeutische Biologie. Drogen und ihre Inhaltsstoffe, Gustav Fischer Verlag, Stuttgart-New York (1993).Google Scholar
- 10.Methodological Recommendation on the Experimental (Pre-clinical) Investigation of New Pharmaceuticals [in Russian], T. A. Voronina and S. B. Seredenin (eds.), Pharmacological Committee of the Ministry of Public Health, Moscow (2000), pp. 122–136.Google Scholar
- 11.S. Barnes and J. A. Davies, J. Pharmacol. Exp. Ther., 120, 125–136 (1957).Google Scholar