Abstract
Aseries of new N-chloracetyl derivatives have been synthesized proceeding from 4-spirocyclopentane-substituted 1,2,3,4-tetrahydroisoquinolines, 1-phenyl-1-cyclopentylmethylamine, and chloroanhydrides of bromoacetic and α-bromopropionic acids. Reactions of these bromoamides with amines (piperidine, morpholine) yield the title N-acylamino derivatives. The antiarrhythmic properties of the synthesized compounds have been studied.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 7, pp. 16–17, July, 2006.
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Markaryan, É.A., Arustamyan, Z.S., Avetisyan, S.V. et al. Synthesis and antiarrhythmic properties of N-acylamino derivatives of 1,6,7-substituted 1,2,3,4-tetrahydroisoquinoline-4-spirocyclopentanes and their analogs. Pharm Chem J 40, 360–362 (2006). https://doi.org/10.1007/s11094-006-0127-2
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DOI: https://doi.org/10.1007/s11094-006-0127-2